Phases I And Ii Of Biotransformation Of Diazepam

Published in Science in 1961, Julius Axelrod found an N -methyltransferase enzyme capable of mediating biotransformation of tryptamine into DMT in a rabbit’s lung. This finding initiated a still ongoing scientific interest in endogenous DMT production in humans and other mammals. In 1963, approval for use was given to diazepam (Valium), a simplified version of chlordiazepoxide, primarily to counteract anxiety symptoms. Sleep-related problems were treated with nitrazepam (Mogadon), which was introduced in 1965, temazepam (Restoril), which was introduced in 1969, and flurazepam (Dalmane), which was introduced in 1973. [Read More]